Bryan Johnson | Which Supplements Does he take? | Naturecan AU (2025)

In 2021, entrepreneur Bryan Johnson set out to reduce his biological age to 18 years old – continuously measuring every organ in his body, every meal he eats, and every moment of his day. So it’s certainly no surprise that a unique supplement regimen is essential to his success so far.

As popular interest grows in anti-ageing strategies and health optimisation, what can the world’s biggest

teach us about improving our own health and wellbeing?

Bryan Johnson is a tech entrepreneur, futurist, and biohacker best known for founding Kernel, a company focused on developing advanced neurotechnology, and Braintree, a payment processing company acquired by PayPal for $800 million.

He started his ambitious self-experimentation in anti-ageing and health optimisation through his project Blueprint, where he applies a data-driven, scientific approach to slow down his biological ageing.

Bryan Johnson's Blueprint Project is a cutting-edge, data-driven approach to radically slowing down the ageing process and optimising health. The project involves an intensive, personalised regimen aimed at reducing Johnson’s biological age through rigorous scientific protocols. Johnson spends millions annually on treatments, supplements, and medical tests to meticulously monitor and control every aspect of his health, with the goal of reversing his biological age and achieving optimal physical and cognitive performance.

The Blueprint involves a daily routine guided by over 200 biomarkers, including regular blood tests, MRIs, and other advanced diagnostics. Johnson works with a team of doctors and scientists to analyse this data and adjust his protocols, which include specific diets, supplements, exercise, and sleep regimens. His goal is to create a blueprint that others can follow to extend lifespan and improve quality of life, with the ultimate aim of achieving age reversal at the cellular level.

Johnson's project is transparent and highly documented - he shares his results publicly to provide insights on how science and technology can be harnessed to combat ageing and improve long-term health outcomes.

Johnson’s supplement routine is not static – it's adjusted based on continuous monitoring of over 200 health markers. He works with a team of doctors to tailor his supplement stack to his individual biological needs, ensuring that each supplement is used to target specific health outcomes. This precision ensures that he’s only taking what his body needs and maximising the effectiveness of the supplementation.

Through the Blueprint Project, Bryan Johnson demonstrates how supplements, when used in combination with other health strategies like diet, exercise, and technology, can be a key component in achieving longevity and optimised health.